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Born in South Jamaica, Queens, Jackson began drug dealing at the age of twelve during the 1980s crack epidemic. After leaving drug dealing to pursue a rap career, he was shot at and struck by nine bullets during an incident in 2000. After releasing his album Guess Who's Back? in 2002, Jackson was discovered by rapper Eminem and signed to Interscope Records. With the help of Eminem and Dr. Dre, who produced his first major commercial successes, Jackson became one of the world's highest selling rappers. In 2003, he founded the record label G-Unit Records, which signed several successful rappers such as Young Buck, Lloyd Banks, and Tony Yayo.

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Jackson has engaged in feuds with other rappers including Ja Rule, Nas, Fat Joe, Jadakiss, Cam'ron, Puff Daddy, Rick Ross, and former G-Unit members The Game and Young Buck. He has also pursued an acting career, appearing in the semi-autobiographical film Get Rich or Die Tryin' in 2005, the Iraq War film Home of the Brave in 2006, and Righteous Kill in 2008. 50 Cent was ranked as the sixth best artist of the 2000s by Billboard magazine. The magazine also ranked him as the fourth top male artist and as the third top rapper behind Eminem and Nelly. Billboard magazine also ranked him as the sixth best and most successful Hot 100 Artist of the 2000s and as the number one rap artist of the 2000s. Billboard ranked his album Get Rich or Die Tryin' as the twelfth best album of the 2000s and his album The Massacre as the 37th best album of the 2000s. As of September 2011, 50 Cent is working on his yet-to-be-titled fifth studio album, which is set to be released in December 2011.

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Curtis Jackson III grew up in the South Jamaica neighborhood of Queens, in New York City. He grew up without a father and was raised by his mother, Sabrina, who gave birth to him at the age of fifteen. Sabrina, a cocaine dealer, raised Jackson until the age of twelve, when she was killed in 1988. Twenty-seven at the time, she became unconscious after someone drugged her drink. She was then left for dead after the gas in her apartment was turned on and the windows shut closed. After her death, Jackson moved into his grandparents' house with his eight aunts and uncles. He recalls, "My grandmother told me, 'Your mother's not coming home. She's not gonna come back to pick you up. You're gonna stay with us now.' That's when I started adjusting to the streets a little bit".